I can confirm this issue too. It also happened in the past but now it also happens again, even more often.
I don't know if this issue is happening when I have my phone in a pocket and not laying anywhere down, but I can confirm if I travel with the train and my mobile connection is getting worst in some areas, this issue happens way more often. I must reconnect the USB-C to Headphone Jack connector many times to get the problem solved and in really weird low connection areas the sound quality volume is also not the same, sometimes on the same settings louder, and sometimes quieter. If think everything has to do with the same issue and maybe your Audioassistant software needs an Update/Fix
@Gustav_ASUS this is really a big issue that has to be solved ASAP, please.