I'm having the same issue with my ZenBook Pro Duo UX581LV. Started freezing a about 3-4 weeks ago and it just keeps getting worse. Updating Nvidia/BIOS/Windows doesn't seem to help at all. Such a freeze first affects all the program windows and tabs, then the mouse and finally the sound. Even though it mostly happens when using CAD software (like Rhino/ArchiCAD) or Photoshop, it also happens when only chrome and a couple of folders are open.
I keep losing work/time/patience daily due to hard resets and resulting loss of work.
Has anyone actually managed to resolve the problem completely?