How many NVMe drives can run on this motherboard while having SATA drives + other questions

[davidhelp]

I want to upgrade my pc as it is from 2015. I am learning about the newer tech.
I currently have a Intel Core i5 4690K @ 3.50GHz and a Samsung ssd as my 'C' drive with two internal sata 7,200rpm drives plus a 4095MB NVIDIA GeForce GTX 1650 graphics card and 32.0GB Dual-Channel DDR3 @ 665MHz

Questions:
1) How many NVMe drives can run on this motherboard below while having SATA drives plugged in?
I understand it has something to do with 'lanes' and if a SATA drive is plugged in then one of the NVMe ports will not work.

2) Is that still true for this motherboard or will all NVMe drives and SATA drives work.

3) Also should I be looking at boards with U.2 ports or just buy a card to plug in the future?

4) I would need a new ATX size case that will have these Thunderbolt & USB ports.
Any recommendations?

I am looking at this one. Any other recommendations would be welcome.
It has 3 x M.2 PCIe 4.0 x4 mode and 4 x SATA 3.0 ports
Also Thunderbolt Header + USB 3.2 Gen 1 header
USB 3.2 Gen 2x2 Type-C Connector

Intel® W680 (LGA 1700) ATX motherboard, PCIe® 5.0, DDR5, dual Intel® 2.5 Gb Ethernet, three PCIe 4.0 M.2 slots, USB 3.2 Gen 2x2 front panel connector, SlimSAS, SATA 6 Gbps, HDMI®, DisplayPort and VGA
https://www.asus.com/us/motherboards-components/motherboards/workstation/pro-ws-w680-ace/

Can use up to a 13th Gen Intel i9 13900K cpu and max 128GB ram

Specs
https://www.asus.com/us/motherboards-components/motherboards/workstation/pro-ws-w680-ace/techspec/

[davidhelp · Accepted solution]

This might be the answer:   https://forum.level1techs.com/t/asus-pro-ws-w680-ace/192319/3

"You can choose to use those four chipset lanes for SATA drives or a fourth Gen4 x4 NVMe drive"

It looks then I can use 3 NVMe drives and plug in my 2 internal SATA drives without a conflict.

[Jiaszzz_ASUS]

Hello, @davidhelp 

Based on your description, may I ask if you have not yet purchased the Pro WS W680-ACE?
In your hypothetical scenario, how many SATA devices do you plan to install and how many NVMe devices will you be running simultaneously?
Regarding the selection of U.2 and the case, we recommend choosing based on your usage needs and habits while also matching the specifications of your motherboard.

Thank you.

[davidhelp]

Not purchased. Now looking at the Asus ProArt Z790-CREATOR WIFI 
I will have 2 NVMe drives and 2 SATA 7,200 drives plugged into the board.